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A Framework for the Design of Knowledge-Based Systems in Structural Biology

Brinkley, James F and Prothero, J. S. and Prothero, John W and Rosse, Cornelius (1989) A Framework for the Design of Knowledge-Based Systems in Structural Biology. In Proceedings, 15th Annual Symposium on Computer Applications in Medical Care, pages pp. 61-65.

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Structural biology is a basic medical science dedicated to understanding the function of the body in terms of its three-dimensional organization. Since both normal and abnormal function are fundamentally determined by structure a knowledge base of structural biology should lead to causally-based problem-solving modules in basic science and clinical medicine. Such a knowledge base, and the associated knowledge-based systems, will be large and will need to be developed and coordinated through many research groups. We describe a distributed framework for allowing such sharing to take place, in which individual modules running on widely scattered and diverse machines are made available as knowledge and data servers communicated via remote procedure calls or similar mechanisms. We also describe potential modules for structural biology and present results from our current modules for computing three-dimensional anatomic reconstructions from serial sections.

Item Type:Conference Paper
Keywords:atlas96 brain95 braincr96 kaz96 knowledge-base nihcv scamc95 sig slisp95
Subjects:SIG Publications
ID Code:21
Deposited By:Hinshaw, Kevin
Deposited On:01 May 2003