BioMediator data integration: beyond genomics to neuroscience data

Wang, Kelan and Tarczy-Hornoch, Peter and Shaker, Ron and Mork, Peter and Brinkley, James F (2005) BioMediator data integration: beyond genomics to neuroscience data. In Proceedings, American Medical Informatics Association Fall Symposium, pages pp. 779-783, Washington, DC.

Abstract

The BioMediator system developed at the University of Washington (UW) provides a theoretical and prac-tical foundation for data integration across diverse biomedical research domains and various data types. In this paper we demonstrate the generalizability of its architecture through its application to the UW Human Brain Project (HBP) for understanding lan-guage organization in the brain. We first describe the system architecture and the characteristics of the four data sources developed by the UW HBP. Second we present the process of developing the application prototype for HBP neuroscience researchers posing queries across these semantically and syntactically heterogeneous neurophysiologic data sources. Then we discuss the benefits and potential limitations of the BioMediator system as a general data integration solution for different user groups in genomic and neuroscience research domains.