Differences Among Cell-structure Ontologies: FMA, GO, & CCO

Au, Alan and Li, Xiang and Gennari, John H (2006) Differences Among Cell-structure Ontologies: FMA, GO, & CCO. In Proceedings, Proceedings, Annual Fall Symposium of the American Medical Informatics Association, pages pp. 16-20.

Abstract

When different groups create models or ontologies of the same knowledge domain, this creates challenges for knowledge sharing. To identify these challenges, we compare cellular structure as modeled by the Foundational Model of Anatomy (FMA), the Gene Ontology (GO), and the Cell Component Ontology (CCO). Although these ontologies all model the physical anatomy of a cell, the actual differences among them are substantial. In this paper, we provide a description and analysis of these differences.