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The OBO Foundry: Coordinated Evolution of Ontologies to Support Biomedical Data Integration

Smith, Barry and Ashburner, Michael and Rosse, Cornelius and Bard, Jonathan and Bug, William and Ceusters, Werner and Goldberg, Louis J and Eilbeck, Karen and Ireland, Amelia and Mungall, Christopher J and OBI Consortium, The and Leontis, Neocles and Rocca‐Serra, a b and Ruttenberg, Alan and Sansone, Susanna-Assunta and Shah, Migam and Whetzel, Patricia L and Lewissi, Suzanna (2007) The OBO Foundry: Coordinated Evolution of Ontologies to Support Biomedical Data Integration. Nature Biotechnology 25(11):pp. 1251-1255. doi:10.1038/nbt1346.

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Abstract

The value of any kind of data is greatly enhanced when it exists in a form that allows it to be integrated with other data. One approach to integration is through the annotation of multiple bodies of data using common controlled vocabularies or ‘ontologies’. Unfortunately, the very success of this approach has led to a proliferation of ontologies, which itself creates obstacles to integration. The Open Biomedical Ontologies (OBO) consortium has set in train a strategy to overcome this problem. Existing OBO ontologies, including the Gene Ontology, are undergoing a process of coordinated reform, and new ontologies being created, on the basis of an evolving set of shared principles governing ontology development. The result is an expanding family of ontologies designed to be interoperable, logically well-formed, and to incorporate accurate representations of biological reality. We describe the OBO Foundry initiative, and provide guidelines for those who might wish to become involved in the future.

Item Type:Journal (Paginated)
Keywords:FMA Open Biomedical Ontologies
Projects:Foundational Model of Anatomy
Subjects:SIG Publications
ID Code:211
Deposited By:Franklin, Joshua Daniel
Deposited On:14 September 2007
Alternative Locations:http://www.nature.com/nbt/journal/v25/n11/full/nbt1346.html